Bomb dropped in the the Nangahar Province in Northeast Afghanistan near the Pakistan border.
The bomb is targeted at Islamic state caves - not only destroying the tunnels but also killing those who may be in those tunnels.
*Source CNN
The GBU-43 bomb is known as the "Mother of all Bombs". It is the largest non-nuclear bomb in the US arsenal. It has not been used before in combat according to the CNN report.
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Here is a video about the bomb.