The US and Japan are planning 2+2 economic talks in Washington DC
- July 29
In the context here 2 + 2 refers to the meeting being attended by foreign and trade ministers from Japan and the secretaries of state and commerce from the US side.
The "two-plus-two" is a new sort of framework for talks. The meeting has been in the works since at least January. Talks will cover economic issues, trade & economic security,
I guess jargon serves a purpose.
Kishida and Biden earlier this year: